BIOTRANSFORMACION DEL PARACETAMOL PDF

El paciente puede experimentar dolor en el cuadrante derecho superior. En el Reino Unido, las ventas de aparador de paracetamol han sido limitadas a cajas de tabletas de 32 x mg en farmacias y cajas de tabletas de 16 x mg en comercios que no son farmacias. En ocasiones particulares, estos efectos adversos pueden llegar a representar una amenaza para la vida del paciente, sobre todo en pacientes con asma. De Wikipedia, la enciclopedia libre. Cuando se haya corregido, puedes borrar este aviso. Este aviso fue puesto el 24 de diciembre de

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Cytochrome P activity and its alteration in different diseases. The diversity of reactions catalyzed and its extensive substrate specificity render CYP enzymes as one of the most versatile known catalysts. Individual members of the CYP superfamily are expressed in almost every cell type in the body.

As compared to hepatic enzymes, the regulation of human extrahepatic CYPs has not been so well studied. In general, the levels of some hepatic CYP enzymes are depressed by diseases, causing potential and documented impairment of drug clearence and clinical drug toxicity.

However, modulation of CYPs is enzyme selective and this selectivity differs in different diseases. Recibido el 11 de junio, Financiamiento: Proyecto Fondecyt Figura 3. Enzimas CYP en el ser humano. Este hecho es poco probable que ocurra en el hombre, porque este efecto es aparentemente dependiente de los receptores a activados por proliferadores peroxisomales PPAR a , cuyos niveles son bajos en los humanos Diabetes mellitus.

Biochemistry of Cytochrome P Raven Press, Ltd. Chapter 27, Ding X, Kaminsky LS. Human extrahepatic cytochromes p Function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts.

Annu Rev Pharmacol Toxicol ; Oxygen and xenobiotic reductase activities of cytochrome P Crit Rev Toxicol ; Microsomal cytochrome P and eicosanoid metabolism. Cell Mol Life Sci ; Role of cytochrome P enzymes and metabolites of arachidonic acid in the control vascular tone. J Vasc Res ; Cytochrome P progress and predictions. Guengerich FP. Cytochromes P of human liver. Classification and activity profiles of the major enzymes. In: Advances in drug metabolism in man.

Guengerich P. Uncommon P catalysed reactions. Curr Drug Metabolism ; 2: Hollenberg PF. Mechanism of cytochrome p and peroxidase catalysed xenobiotic metabolism. Omura T. Forty years of Cytochrome P Biochem Biophys Res Commun ; P superfamily. Up date of new sequences, gene mapping, accession numbers and nomenclature.

Pharmacogenetics ; 6: A method for the simultaneous evaluation of the activities of seven major human drug metabolizing cytochrome Ps using in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry. Drug Metab Dispos ; Evaluation of cytochrome p probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions.

Lin JH, Lu A. Inhibition and induction of cytochrome P and the clinical implications. Clin Pharmacokinetic ; Whitlock JPJ. Induction of cytochrome PA1. Lieber CS. Cytochrome PE1: its physiological and pathological role. Physiol Rev ; The CYP2E subfamily. Cheng P, Morgan E. Hepatic cytochrome p regulation in disease states. Current Drug Metabolism ; 2: Cytochrome p 2E1 in diabetic and obese patients as assessed by chlorzoxazone hydroxylation.

Fundam Clin Pharmacol ; Epoxyeicosatrienoic acid-mediated renal vasodilatation to arachidonic acid is enhanced in SHR. Hypertension ; Farrell G. Effects of disease on expression and regulation of CYPs. Mol Aspects Med ; Roman R. P metabolites of arachidonic acid in the control of cardiovascular function.

Imig JD. Eicosanoid regulation of the renal vasculature. Formation of hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney.

J Biol Chem ; Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy induced hypertension. Differential regulation of natriuresis by hidroxyeicosatetraenoic acid in human salt sensitive versus salt resistant hypertension. Circulation ; Morgan ET. Regulation of cytochrome P by inflammatory mediators: Why and how? Modulation of cytochrome P gene expression in endotoxemic mice is tissue specific and peroxisome proliferator activated receptor alpha dependent.

J Pharmacol Exp Ther ; Peroxisome proliferator activated receptor alpha expression in human liver. Mol Pharmacol ; Altered theophylline clearence during an influenza B outbreak. Pediatrics ; The roles of cytochrome P 3A4 and 1A2 in the 3-hydroxylation of quinine in vivo.

Clin Pharmacol Ther ; Depression of drug metabolizing activity in the human liver by interferon beta. Hepatology ; Shimojo N. Cytochrome P changes in rats with streptozocin induced diabetes. Int J Biochem ; Growth hormone dependent and independent regulation of cytochrome P isozyme expression in streptozotocin diabetic rats. Endocrinology ; Non alcoholic steatosis and steatohepatitis II. Cytochrome P enzymes and oxidative stress. Peroxisome proliferator activated receptor alpha controls the hepatic CYP4A induction adaptive response to starvation and diabetes.

Theophylline metabolism in healthy non smokers and in patients with insulin dependent diabetes mellitus. Leptin and the regulation of body weight in mammals. Nature ; Chlorzoxazone, a selective probe for phenotyping cyp2E1 in humans. Pharmacogenetics ; 9: Cytochrome P 2A6, 2E1, and 3a, and production of protein-aldehyde adducts in the liver of patients with alcoholic and non alcoholic liver diseases. J Hepatol ; Hepatic cytochrome PE1 is increased in patients with non alcoholic steatohepatitis.

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