Fundic gland polyps allegedly increased in frequency in recent decades, and had attracted great attention due to possible association with prolonged proton pump inhibitor therapy. Prolonged use of this drug could cause parietal cell hyperplasia, obstruction of glandular lumen and cystic dilation of the gland. This study aims to analyze clinical and pathological features of fundic gland polyps in patients with and without proton pump inhibitor therapy in a selected population from Brazil. It was selected a sample of Brazilian patients 78 females and 23 males , from a five years retrospective search of the files from a private pathology laboratory. The patients had an average age of 57 years and we included patients with a histological diagnosis of fundic gland polyp. The clinical data were obtained from their files and all histological slides were reviewed and examined with hematoxylin and eosin HE and Giemsa.

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Background: Studies with latest technologies such as endoscopy with magnification and chromoendoscopy showed that various endoscopic aspects are clearly related to infection by Helicobacter pylori HP.

The description of different patterns of erythema in gastric body under magnification of images revived interest in identifying these patterns by standard endoscopy. Aim: To validate the morphologic features of gastric mucosa related to H. Methods: Prospective study of consecutive patients with the standard videoendoscope image analysis were obtained, recorded and stored in a program database.

These images were studied with respect to the presence or absence of H. Were studied: a normal mucosa appearance; b mucosal nodularity; c diffuse nonspecific erythema or redness with or without edema of folds and exudate of antrum and body; d mosaic pattern with focal area of hyperemia; e erythema in streaks or bands red streak ; f elevated raised erosion; g flat erosions; h fundic gland polyps.

The main exclusion criteria were the use of drugs, HP pre-treatment and other entities that could affect results. Results: Applying the exclusion criteria, were included of the patients, of which 52 On the positive findings, the most associated with infection were: nodularity in the antrum On the negative group the normal appearance of the mucosa was Conclusion: Endoscopic findings are useful in the predictability of the result and in directing biopsies.

The most representative form of HP related gastritis was the nodularity of the antral mucosa. The raised erosion and mucosa in mosaic in the body are suggestive but not specific to the infection. The other forms were not conclusive of the presence of HP. A mais representativa forma de gastrite por HP foi o achado de nodularidade na mucosa antral. Conflicts of interest: none. Endoscopic findings related to the positive HP: A antral nodularity; B raised erosions;….

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Full-text links Cite Favorites. Abstract in English , Portuguese , Portuguese. Conflict of interest statement Conflicts of interest: none. Endoscopic findings related to the….

Endoscopic findings related to negative…. Endoscopic findings related to negative HP: A normal appearance of the gastric body…. See this image and copyright information in PMC. Similar articles Diagnosis of Helicobacter pylori infection in gastric mucosa by endoscopic features: a multicenter prospective study. Kato T, et al. Dig Endosc. Epub Jan Close observation of gastric mucosal pattern by standard endoscopy can predict Helicobacter pylori infection status.

Cho JH, et al. J Gastroenterol Hepatol. PMID: Labenz J, et al. Dtsch Med Wochenschr. PMID: German. Ohkusa T, et al. Nihon Rinsho. PMID: Review. Yin YF, et al. Show more similar articles See all similar articles. Cited by 3 articles A systematic review of the role of non-magnified endoscopy for the assessment of H. Glover B, et al. Endosc Int Open. Linked color imaging confers benefits in profiling H. Sun X, et al. Epub Jul 3. Frugis S, et al. Arq Bras Cir Dig.

Clinical Trial. High-resolution magnification endoscopy can reliably identify normal gastric mucosa, Helicobacter pylori associated gastritis, and gastric atrophy. Gastritis: terminology, etiology, and clinicopathological correlations: another biased view. Hum Pathol. High definition endoscopy and "narrow band imaging" in the diagnosis of gastroesophageal reflux disease.

Endoscopic features of Helicobacter pylori-related gastritis. Endoscopic nodular gastritis an endoscopic indicator of high-grade bacterial colonization and severe gastritis in children with Helicobacter pylori. J Pediatr Gastroenterol Nutr.

Publication types Observational Study Actions. MeSH terms Adolescent Actions. Adult Actions. Aged Actions. Aged, 80 and over Actions. Cross-Sectional Studies Actions. Female Actions. Humans Actions. Male Actions. Middle Aged Actions. Prospective Studies Actions.

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Gastric polyps: analysis of endoscopic and histological features in our center. Department of Gastroenterology. Madrid, Spain. Background and objective: the prevalence of gastric polyps in esophagogastroduodenoscopies EGDs ranges between 0. The relative frequency of histological subspecies varies widely among published series.





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